“I was really mad, I was really upset,” Aguilar recalls of when he first saw the desecration a few weeks ago. “Imagine you come here with your family to celebrate the death of a loved one’s anniversary and you see that.

Hmmm, that’s a really good question. Maybe the oil and gas industry was more convincing to “those that are paid to think” and “those that know better?” Who knows? Will likely remain a my$tery.

He realized that the movement of the wood lice had no larger purpose, at least not in the sense that a human has a purpose when getting in a car to run an errand. The creatures’ movement was random; they simply moved faster in the warmth4 of the sun.

Olivia Cole, 75. She won an Emmy Award for her portrayal of Matilda, wife to Chicken George, in the landmark miniseries “Roots.” Jan. 19.

Ask Kinmen residents what they feel about Xiamen and mainland Chinese and they might first point out that rubbish is floating over from them to Kinmen’s shores—complete with their simplified Chinese labels (in contrast to Taiwan’s traditional Chinese).

Based on the reported structural and subcellular distribution differences between CUL4A and CUL4B, we hypothesized that there are specific CUL4A and CUL4B requirements for different HIV phenotypes. Previous work showing that HIV-1 Vpr triggers G2 cell cycle arrest by eliciting DNA damage signals (37, 62–66) led us to hypothesize that NLS-containing CUL4B is required for this function. Reports showing that SAMHD1 depletion is triggered in the nucleus (67–69) led us to posit that CUL4B is required for this phenotype as well. UNG2 can be found in both the cytoplasm and the nucleus (38), suggesting that HIV-1 Vpr-directed UNG2 degradation could be set off through CUL4A or CUL4B. In this work, we investigated the need for CUL4A and/or CUL4B for the Vpr and Vpx phenotypes that require the CRL4 ubiquitin ligase and show that the two CUL4 types are exchangeable for G2 cell cycle arrest, UNG2 turnover, and SAMHD1 depletion. Furthermore, we show that in primary human monocyte-derived macrophages (hMDMs), both CUL4 types are required for optimal SAMHD1 depletion by Vpx. Finally, we demonstrate that the subcellular distributions of CUL4A and CUL4B can vary between cell types.

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Roy Clark, 85. The country star and guitar virtuoso who headlined the cornpone TV show “Hee Haw” for nearly a quarter century and was known for such hits as “Yesterday, When I Was Young” and “I Never Picked Cotton.” Nov. 15.

The headers, too, with their distinctive wraparound collectors, were built by Bobby to mimic the pipes on the SWO Willys. “At the time it was a convenient way to pull the tubes together, and it looked neat on the weed burners,” Del explains.

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The Australian entrepreneur believes these rocks, formed over millions of years at the bottom of the ocean, can help satisfy the growing demand for the metals used in batteries and clean energy technologies, and are therefore critical to the transition away from fossil fuels. Less than 20cm wide, the so-called nodules can contain nickel, manganese, copper and cobalt— all set to see a surge in demand over the next decade.