The only time that I will pay attention to your statements is if you build a house in Alberta without connections to the electrical grid, fireplace and gas system. Then live in it for 12 months continuously, Cooking your food, heating your house, doing your laundry, keep your food from spoiling. Survive in -20C in the winter and + 30 in the summer. Mr. Voutsinos offered to “Environment Lethbridge” to sponsor such a project and to pay all their expenses and profit. They did not like the request for a secure monitoring system. Unfortunately they want to only talk about it the same as you do.

My cowboy camp in upper Conness Creek on the Yosemite High Route in August. (My quilt was air-drying in a nearby bush.) Nighttime temperatures were normally in the high 30s to low 40s, and I found the Insulated AXL to be sufficiently warm. (Andrew Skurka)

The owner of La Chiquita saw something in Aguilar that even the artist didn’t quite see — a work in the grand Mexican style of large outdoor murals. When Aguilar asked what the owner envisioned, he was told, “Just paint something beautiful.”

The Saskatchewan Conservation House had no furnace. Instead, it relied on a system that collected solar heat during the day, stored it in a water tank, then released the heat at night. All told, the house required less than a quarter of the energy consumed by a standard home of the time. Some 30,000 people toured the house. Its success led to the construction of more demonstration homes in Saskatoon. An article in a 1981 issue of Popular Science was titled, ‘Super-insulation: Saskatchewan leads the parade.’

To talk about ‘4 percent of nameplate capacity’ is grossly misleading and, in fact, makes no sense. If you want to talk about performance you have to compare the expected energy produced (based on solar models for the location) to actual energy produced. If that energy is sold to the grid and the operators can make money, you have what we call a ‘business’. This is what has been happening in Alberta for more than 20 years, under multiple governments.

The capital expenditures were $20 million in 2018, a third less than 2017, as we completed the international ERP implementation in 2017. In 2019, we expect capital expenditures to be approximately $25 million, with the increase coming from additional investments in technology, e-commerce and expanded capabilities at the La Porte RDC.

“We are delighted to win such a prestigious award,” added Mr Davidson. “It is a fantastic honour and testament to the skill, dedication and expertise of our staff, whose continued passion for excellence has enabled us to continue to grow, innovate and ensure that system design and installation, as well as our after sales service, continues to be of the highest standard.

19mar(mar 19)7:00 pm18jun(jun 18)8:30 pmCMS Community Chorus7:00 pm – (june 18) 8:30 pm Holy Trinity Lutheran Church

Comedy Open Mic! @Tudor Lounge with host Don Johnson is your late night spot for the darkest comedy in the city of Buffalo. Come for the drink specials, stay for

The reported differences between CUL4A and CUL4B led us to hypothesize that Vpr-mediated G2 cell cycle arrest relies heavily, if not exclusively, on NLS-containing CUL4B. This hypothesis was based on work linking Vpr-triggered G2 arrest to nuclear events. In both HEK293T cells and primary T cells, we found both CUL4 forms to be abundant in the cytosol. Interestingly, both CUL4 types were also detected in the nucleus in a predominately neddylated, and therefore presumably more active, form. We hypothesize that the nearly identical distribution patterns for CUL4A and CUL4B are the reason for their functional interchangeability in this scenario.

Lindy in the Buff 2019 By popular demand, Swing Buffalo is bringing back Lindy in the Buff, a Lindy Hop workshop weekend with the incredibly talented Caitlin Wellman from Toronto! The beginner/intermediate

The amino acid sequence similarity between CUL4A and CUL4B suggests that the two proteins could be interchangeable, but this is not the case. No humans who lack functional CUL4A have been identified, likely due to a role in spermatogenesis similar to that observed for mice (52). Human males lacking functional CUL4B present with X-linked intellectual disability (XLID), while female carriers are unaffected (53–56). Nakagawa and Xiong showed previously that WDR5, an H3K4 methyltransferase, is specifically depleted by CUL4B, but not by CUL4A, and that this determines neuronal gene expression profiles (57). CUL4A overexpression has been associated with breast cancer (58), hepatocellular carcinoma (59), and pleural mesothelioma (60). A complementary observation showed that skin-specific deletion of CUL4A protected mice against UV-induced skin cancer (61).