We expect to file our 2018 annual report on Form 10-K later today, and it will also be available on our website. Please note that the information reported on this call speaks only as of today, February 15, 2019 and, therefore, you are advised that information may no longer be accurate as of the time of replay.

Flexible Work Options; 11/15; 12:30-1:30 p.m. This presentation will provide an overview of Flexible Work Options and provide guidelines for proposing and implementing a flex request including: understanding the applicable HR guidelines and policies, assessing the fit between position and job responsibilities, reviewing a sample proposal, documenting the flexible work option request and implementing the request.

The public is invited to attend a FREE informational seminar at Asbury Pointe Retirement Community to learn all about the convenient, maintenance-free lifestyle that retirement community living provides. Guests will be able to tour the grounds, including the beautifully-appointed apartments featuring such amenities as granite countertops, stainless steel appliances and custom cupboards, speak to current residents, get answers to the many questions they have and enjoy delicious refreshments. Asbury Pointe’s seminars are free and open to the public; reservations are not required. For more information, call (716) 810.7500. Additional seminars to be held throughout 2019 – visit www.beechwoodcare.org for more information.

Over time, Hinton convinced Friston that the best way to think of the brain was as a Bayesian probability machine. The idea, which goes back to the 19th century and the work of Hermann von Helmholtz, is that brains compute and perceive in a probabilistic manner, constantly making predictions and adjusting beliefs based on what the senses contribute. According to the most popular modern Bayesian account, the brain is an “inference engine” that seeks to minimize “prediction error.”

Over the course of its three-month search process, the Committee and its consultants contacted and considered more than 140 individuals for the position. From this group, the committee evaluated an initial pool of 55 nominees and applicants and ultimately selected 8 individuals for semi-finalist interviews with the entire Committee. Based on voluntary self-identifications and other sources, we believe the initial pool of 55 contained 17 women and 38 men, and eight persons of color. The six individuals recommended for consideration to the President included one woman and four people of color.

Got it. Then a little bit more of a — what management is focused on question. If you look back over the last few years, you’ve had 2015 revenue down in the 20s; 2016 revenue down in the 30s; 2017, up 20%; 2018, up 15%. Generally, I find companies then can’t focus on operational improvement and optimizing the business processes, you’re — in the downturn you’re focused on restructuring, in the upturn you’re focused on inventory and customer service.

Strategize marketing, market-entry, market expansion, and other business plans by gaining knowledge of the factors affecting growth in the market and purchase decisions of buyers.

Six, Eight, and 10-speed automatic transmissions are available depending on the customers engine choice. Six-speeds are available on 4.3-liter V6 and 5.3-liter V8 models, eight-speeds are available on 2.7-liter turbocharged four-cylinder and 5.3-liter V8 models, and 10-speeds are available on 6.2-liter V8 models and the aforementioned 3.0-liter inline six-cylinder Turbo Diesel engine.

American Repertory Theater of WNY Presents HEATHERS: THE MUSICAL Scheduled to get the 2018-19 season off to explosive start is the local premier of the musical based on the 1988 cult-classic

Synopsis: A picture is worth 1,000 words — what about a song? Can a picture inspire a song or fifteen? In 35mm, each photo creates an unique song, moments frozen in time; a glimmer of a life unfolding, a glimpse of something happening. A stunning new multimedia musical which explores a groundbreaking new concept in musical theatre… This intricately woven collection of stories told through song re-imagines what the modern American musical can be.

The All Night Kanye Party is a collaborative community event that will be like nothing you’ve ever experienced, unless you came to the first one.

Interestingly, we did not observe SAMHD1 to be exclusively nuclear, as reported in a number of studies relying on immunofluorescence. Our observations are most consistent with those of Baldauf et al., who used both 3-dimensional imaging and subcellular fractionation of resting and activated T cells and of macrophages to show that SAMHD1 can be found in both the nucleus and cytoplasm (105). Of course, it is also possible that the intracellular distribution of SAMHD1 varies among cell types and with proliferation status.